Wobbliness (ataxia) after Lotilaner (Credelio) in dogs

277 reports to the FDA describe wobbliness (ataxia) in dogs given Lotilaner. That is 2.8% of all reports for this medicine, compared with 2.6% across reports for all dog medicines.

277Reports

44%Marked serious

31%Recovered

8.3%Died or euthanised

1 daysTypical onset

How soon it started

Same day

84 34%

1–2 days

61 24%

3–7 days

13 5.2%

1–4 weeks

26 10%

Over a month

65 26%

How the animals did

Recovered

87 31%

Still unwell when reported

121 44%

Died

7 2.5%

Euthanised

16 5.8%

Not known

46 17%

Problems reported at the same time

88 32%

83 30%

61 22%

52 19%

45 16%

39 14%

31 11%

29 10%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lotilaner kills fleas and ticks; monthly chewable.

Products with this ingredient include Credelio. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Lotilaner cause wobbliness (ataxia) in dogs?: 277 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Wobbliness (ataxia) with similar medicines

Wobbliness (ataxia) after Fluralaner (Bravecto) 1,189 reports · 1.7% of its reports
Wobbliness (ataxia) after Afoxolaner (NexGard) 1,333 reports · 2.3% of its reports
Wobbliness (ataxia) after Sarolaner (Simparica) 1,086 reports · 6.5% of its reports
Wobbliness (ataxia) after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 139 reports · 1.5% of its reports
Wobbliness (ataxia) after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) 52 reports · 1.7% of its reports

All reported side effects of Lotilaner in dogs · Medicines most reported with wobbliness (ataxia)