Vocalising after Afoxolaner (NexGard) in dogs

793 reports to the FDA describe vocalising in dogs given Afoxolaner. That is 1.4% of all reports for this medicine, compared with 1.2% across reports for all dog medicines.

793Reports

48%Marked serious

32%Recovered

10%Died or euthanised

1 daysTypical onset

How soon it started

Same day

283 42%

1–2 days

155 23%

3–7 days

65 9.6%

1–4 weeks

79 12%

Over a month

93 14%

How the animals did

Recovered

252 32%

Recovered with lasting effects

2 0.3%

Still unwell when reported

68 8.6%

Died

35 4.4%

Euthanised

46 5.8%

Not known

390 49%

Problems reported at the same time

204 26%

179 23%

172 22%

152 19%

147 19%

136 17%

130 16%

128 16%

Age of the animals

Under 1 year

164

1–3 years

180

4–7 years

172

8–11 years

145

12+ years

100

About this medicine

Afoxolaner kills fleas and ticks; given as a monthly chewable.

Products with this ingredient include NexGard. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Afoxolaner cause vocalising in dogs?: 793 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Vocalising with similar medicines

Vocalising after Fluralaner (Bravecto) 636 reports · 0.9% of its reports
Vocalising after Sarolaner (Simparica) 174 reports · 1.0% of its reports
Vocalising after Lotilaner (Credelio) 142 reports · 1.4% of its reports
Vocalising after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 75 reports · 0.8% of its reports
Vocalising after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) 41 reports · 1.3% of its reports

All reported side effects of Afoxolaner in dogs · Medicines most reported with vocalising