Vocalising after Fluralaner (Bravecto) in dogs

The FDA has received 636 reports of vocalising in dogs after Fluralaner. That is 0.9% of all reports for this medicine, compared with 1.2% across reports for all dog medicines.

636Reports

82%Marked serious

26%Recovered

17%Died or euthanised

1 daysTypical onset

How soon it started

Same day

146 34%

1–2 days

133 31%

3–7 days

36 8.4%

1–4 weeks

41 9.5%

Over a month

74 17%

How the animals did

Recovered

155 24%

Recovered with lasting effects

8 1.3%

Still unwell when reported

279 44%

Died

49 7.7%

Euthanised

60 9.4%

Not known

85 13%

Problems reported at the same time

214 34%

178 28%

158 25%

152 24%

142 22%

137 22%

110 17%

86 14%

Age of the animals

Under 1 year

1–3 years

143

4–7 years

184

8–11 years

148

12+ years

About this medicine

Fluralaner kills fleas and ticks for up to 12 weeks (chewable or spot-on).

Products with this ingredient include Bravecto. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Fluralaner cause vocalising in dogs?: 636 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Vocalising with similar medicines

Vocalising after Afoxolaner (NexGard) 793 reports · 1.4% of its reports
Vocalising after Sarolaner (Simparica) 174 reports · 1.0% of its reports
Vocalising after Lotilaner (Credelio) 142 reports · 1.4% of its reports
Vocalising after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 75 reports · 0.8% of its reports
Vocalising after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) 41 reports · 1.3% of its reports

All reported side effects of Fluralaner in dogs · Medicines most reported with vocalising