Lethargy after Sarolaner (Simparica) in dogs

The FDA has received 1,852 reports of lethargy in dogs after Sarolaner. That is 11% of all reports for this medicine, compared with 11% across reports for all dog medicines.

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How soon it started

How the animals did

Problems reported at the same time

Age of the animals

About this medicine

Sarolaner kills fleas, ticks and some mites; monthly.

Products with this ingredient include Simparica. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Sarolaner cause lethargy in dogs?

1,852 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.

How soon after a dose was it reported?

In half of the reports with dates, it started within 1 day of the first dose.

What should I do?

Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Lethargy with similar medicines

• Lethargy after Fluralaner (Bravecto) 6,278 reports · 9.1% of its reports
• Lethargy after Afoxolaner (NexGard) 6,825 reports · 12% of its reports
• Lethargy after Lotilaner (Credelio) 1,033 reports · 10% of its reports
• Lethargy after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 747 reports · 8.1% of its reports
• Lethargy after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) 396 reports · 13% of its reports

All reported side effects of Sarolaner in dogs · Medicines most reported with lethargy