Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) side effects in dogs
9,258 reports sent to the FDA between 2023 and 2026 involve Afoxolaner + Moxidectin + Pyrantel in dogs. The most reported problems were vomiting, diarrhea, lethargy. 7.8% were marked serious, and where it was recorded, signs eased after stopping the medicine in 50% of cases.
About this medicine
Afoxolaner kills fleas and ticks; given as a monthly chewable. Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs). Pyrantel treats roundworms and hookworms.
Products with this combination include NexGard PLUS. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.
Most reported side effects
Share = percentage of this medicine's reports that mention the problem. One report can list several problems.
Reports that it didn't work
Some reports are about the medicine not working (for example a dog still getting fleas or heartworm), not about a side effect.
How soon problems started
Time from the first dose to the first sign, where both dates were reported (7,723 reports).
How the animals did
Breeds named most often
Popular breeds appear more often because there are more of them.
- Labrador Retriever 722 reports
- Golden Retriever 450 reports
- German Shepherd Dog 326 reports
- Australian Shepherd Dog 221 reports
- Beagle 194 reports
- Pit Bull 157 reports
- Shih Tzu 144 reports
- French Bulldog 125 reports
- Chihuahua 118 reports
- Yorkshire Terrier 114 reports