Didn't prevent heartworm after Lotilaner (Credelio) in dogs

The FDA has received 487 reports of didn't prevent heartworm in dogs after Lotilaner. That is 4.9% of all reports for this medicine, compared with 13% across reports for all dog medicines, so it is reported less often than average with this medicine.

487Reports

7.2%Marked serious

0.0%Recovered

0.2%Died or euthanised

252 daysTypical onset

How soon it started

Same day

5 2.9%

1–2 days

0 0.0%

3–7 days

0 0.0%

1–4 weeks

6 3.5%

Over a month

159 94%

How the animals did

Still unwell when reported

15 3.1%

Euthanised

1 0.2%

Not known

471 97%

Problems reported at the same time

19 3.9%

15 3.1%

13 2.7%

12 2.5%

12 2.5%

12 2.5%

11 2.3%

Didn't work as expected

11 2.3%

Age of the animals

Under 1 year

1–3 years

333

4–7 years

8–11 years

12+ years

About this medicine

Lotilaner kills fleas and ticks; monthly chewable.

Products with this ingredient include Credelio. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Lotilaner cause didn't prevent heartworm in dogs?: 487 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 252 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Didn't prevent heartworm with similar medicines

Didn't prevent heartworm after Fluralaner (Bravecto) 638 reports · 0.9% of its reports
Didn't prevent heartworm after Afoxolaner (NexGard) 831 reports · 1.5% of its reports
Didn't prevent heartworm after Sarolaner (Simparica) 287 reports · 1.7% of its reports
Didn't prevent heartworm after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 1,168 reports · 13% of its reports
Didn't prevent heartworm after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) 126 reports · 4.1% of its reports

All reported side effects of Lotilaner in dogs · Medicines most reported with didn't prevent heartworm