Weight gain after Lotilaner (Credelio) in dogs

76 reports to the FDA describe weight gain in dogs given Lotilaner. That is 0.8% of all reports for this medicine, compared with 0.6% across reports for all dog medicines.

76Reports
22%Marked serious
9.2%Recovered
7.9%Died or euthanised
94 daysTypical onset
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How soon it started

Same day
6 14%
1–2 days
2 4.8%
3–7 days
3 7.1%
1–4 weeks
4 9.5%
Over a month
27 64%

How the animals did

Recovered
7 9.2%
Still unwell when reported
15 20%
Died
4 5.3%
Euthanised
2 2.6%
Not known
48 63%

Problems reported at the same time

Age of the animals

Under 1 year
4
1–3 years
31
4–7 years
26
8–11 years
3
12+ years
3

About this medicine

Lotilaner kills fleas and ticks; monthly chewable.

Products with this ingredient include Credelio. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Lotilaner cause weight gain in dogs?
76 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 94 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Weight gain with similar medicines

All reported side effects of Lotilaner in dogs · Medicines most reported with weight gain