Spironolactone side effects in dogs

195 reports sent to the FDA between 2011 and 2026 involve Spironolactone in dogs. The most reported problems were loss of appetite, vomiting, lethargy. 54% were marked serious, and where it was recorded, signs eased after stopping the medicine in 100% of cases.

195Reports
54%Marked serious
1.0%Only medicine involved
21%Recovered
18%Died or euthanised
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About this medicine

Type: medicine.

Most reported side effects

52 27%
43 22%
29 15%
Cough
15 7.7%
Weight loss
14 7.2%
Seizures
11 5.6%
Weakness
10 5.1%
Abnormal ultrasound finding
10 5.1%
Wobbliness (ataxia)
9 4.6%
Behaviour change
9 4.6%
Tremors
9 4.6%

Share = percentage of this medicine's reports that mention the problem. One report can list several problems.

Reports that it didn't work

Some reports are about the medicine not working (for example a dog still getting fleas or heartworm), not about a side effect.

Didn't work as expected
16 8.2%
Didn't prevent heartworm
3 1.5%
Didn't stop worms
1 0.5%

How soon problems started

Same day
20 14%
1–2 days
6 4.2%
3–7 days
6 4.2%
1–4 weeks
27 19%
Over a month
84 59%

Time from the first dose to the first sign, where both dates were reported (143 reports).

How the animals did

Recovered
36 18%
Recovered with lasting effects
4 2.1%
Still unwell when reported
56 29%
Died
15 7.7%
Euthanised
21 11%
Not known
63 32%

Breeds named most often

Popular breeds appear more often because there are more of them.

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