Liver problems after Spironolactone in dogs

28 reports to the FDA describe liver problems in dogs given Spironolactone. That is 14% of all reports for this medicine, compared with 4.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

28Reports
64%Marked serious
7.1%Recovered
25%Died or euthanised
68 daysTypical onset
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How soon it started

Same day
3 13%
1–2 days
0 0.0%
3–7 days
1 4.3%
1–4 weeks
6 26%
Over a month
13 57%

How the animals did

Recovered
2 7.1%
Still unwell when reported
7 25%
Died
6 21%
Euthanised
1 3.6%
Not known
12 43%

Problems reported at the same time

Weight loss
7 25%
7 25%

Age of the animals

Under 1 year
0
1–3 years
2
4–7 years
0
8–11 years
10
12+ years
16

About this medicine

Type: medicine.

Questions owners ask

Can Spironolactone cause liver problems in dogs?
28 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 68 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

All reported side effects of Spironolactone in dogs · Medicines most reported with liver problems