Death after Spironolactone in dogs

The FDA has received 36 reports of death in dogs after Spironolactone. That is 18% of all reports for this medicine, compared with 5.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

36Reports
100%Marked serious
0.0%Recovered
100%Died or euthanised
41 daysTypical onset
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How soon it started

Same day
1 3.6%
1–2 days
1 3.6%
3–7 days
4 14%
1–4 weeks
6 21%
Over a month
16 57%

How the animals did

Died
15 42%
Euthanised
21 58%

Problems reported at the same time

10 28%
Weight loss
7 19%
Weakness
5 14%

Age of the animals

Under 1 year
0
1–3 years
1
4–7 years
3
8–11 years
9
12+ years
22

About this medicine

Type: medicine.

Questions owners ask

Can Spironolactone cause death in dogs?
36 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 41 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Death with similar medicines

All reported side effects of Spironolactone in dogs · Medicines most reported with death