Trilostane (Vetoryl) side effects in dogs

11,924 reports sent to the FDA between 2004 and 2026 involve Trilostane in dogs. The most reported problems were loss of appetite, liver problems, lethargy. 46% were marked serious, and where it was recorded, signs eased after stopping the medicine in 67% of cases.

11,924Reports
46%Marked serious
68%Only medicine involved
18%Recovered
11%Died or euthanised
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About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Most reported side effects

Share = percentage of this medicine's reports that mention the problem. One report can list several problems.

Reports that it didn't work

Some reports are about the medicine not working (for example a dog still getting fleas or heartworm), not about a side effect.

Didn't stop fleas
10 0.1%
Didn't stop worms
7 0.1%
Didn't stop ticks
3 0.0%
Didn't prevent heartworm
2 0.0%

How soon problems started

Same day
610 6.8%
1–2 days
490 5.5%
3–7 days
771 8.6%
1–4 weeks
2,068 23%
Over a month
4,992 56%

Time from the first dose to the first sign, where both dates were reported (8,931 reports).

How the animals did

Recovered
2,010 17%
Recovered with lasting effects
82 0.7%
Still unwell when reported
1,389 12%
Died
438 3.7%
Euthanised
908 7.6%
Not known
7,097 60%

Breeds named most often

Popular breeds appear more often because there are more of them.

Other hormone or endocrine medicines for dogs