Excessive urination after Trilostane (Vetoryl) in dogs

772 reports to the FDA describe excessive urination in dogs given Trilostane. That is 6.5% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

772Reports
63%Marked serious
9.5%Recovered
11%Died or euthanised
69 daysTypical onset
SponsoredWorried about your pet? Ask a veterinarian online, 24/7

How soon it started

Same day
35 6.5%
1–2 days
8 1.5%
3–7 days
31 5.8%
1–4 weeks
110 20%
Over a month
353 66%

How the animals did

Recovered
67 8.7%
Recovered with lasting effects
6 0.8%
Still unwell when reported
170 22%
Died
16 2.1%
Euthanised
72 9.3%
Not known
441 57%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
1
4–7 years
73
8–11 years
370
12+ years
315

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause excessive urination in dogs?
772 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 69 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Excessive urination with similar medicines

All reported side effects of Trilostane in dogs · Medicines most reported with excessive urination