Excessive urination after Phenylpropanolamine (Proin) in dogs

The FDA has received 81 reports of excessive urination in dogs after Phenylpropanolamine. That is 2.0% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

81Reports
58%Marked serious
15%Recovered
12%Died or euthanised
20 daysTypical onset
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How soon it started

Same day
10 20%
1–2 days
9 18%
3–7 days
3 6.0%
1–4 weeks
5 10%
Over a month
23 46%

How the animals did

Recovered
12 15%
Still unwell when reported
33 41%
Died
2 2.5%
Euthanised
8 9.9%
Not known
26 32%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
2
4–7 years
18
8–11 years
29
12+ years
31

About this medicine

Phenylpropanolamine treats urinary incontinence.

Products with this ingredient include Proin. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Phenylpropanolamine cause excessive urination in dogs?
81 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 20 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Excessive urination with similar medicines

All reported side effects of Phenylpropanolamine in dogs · Medicines most reported with excessive urination