Liver problems after Phenylpropanolamine (Proin) in dogs

289 reports to the FDA describe liver problems in dogs given Phenylpropanolamine. That is 7.0% of all reports for this medicine, compared with 4.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

289Reports
72%Marked serious
15%Recovered
16%Died or euthanised
14 daysTypical onset
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How soon it started

Same day
51 28%
1–2 days
15 8.3%
3–7 days
16 8.8%
1–4 weeks
24 13%
Over a month
75 41%

How the animals did

Recovered
37 13%
Recovered with lasting effects
6 2.1%
Still unwell when reported
87 30%
Died
17 5.9%
Euthanised
30 10%
Not known
112 39%

Problems reported at the same time

Vomiting
116 40%
Loss of appetite
88 30%
Lethargy
83 29%
Kidney problems
76 26%
Diarrhea
48 17%
Death
47 16%
Blood problems
37 13%
Weight loss
31 11%

Age of the animals

Under 1 year
1
1–3 years
27
4–7 years
49
8–11 years
113
12+ years
97

About this medicine

Phenylpropanolamine treats urinary incontinence.

Products with this ingredient include Proin. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Phenylpropanolamine cause liver problems in dogs?
289 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 14 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

All reported side effects of Phenylpropanolamine in dogs · Medicines most reported with liver problems