Weight loss after Phenylpropanolamine (Proin) in dogs

The FDA has received 123 reports of weight loss in dogs after Phenylpropanolamine. That is 3.0% of all reports for this medicine, compared with 1.7% across reports for all dog medicines, so it is reported unusually often with this medicine.

123Reports
65%Marked serious
14%Recovered
28%Died or euthanised
31 daysTypical onset
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How soon it started

Same day
7 9.7%
1–2 days
10 14%
3–7 days
7 9.7%
1–4 weeks
12 17%
Over a month
36 50%

How the animals did

Recovered
14 11%
Recovered with lasting effects
3 2.4%
Still unwell when reported
25 20%
Died
10 8.1%
Euthanised
25 20%
Not known
46 37%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
9
4–7 years
18
8–11 years
56
12+ years
40

About this medicine

Phenylpropanolamine treats urinary incontinence.

Products with this ingredient include Proin. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Phenylpropanolamine cause weight loss in dogs?
123 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 31 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Weight loss with similar medicines

All reported side effects of Phenylpropanolamine in dogs · Medicines most reported with weight loss