Death after Phenylpropanolamine (Proin) in dogs

311 reports to the FDA describe death in dogs given Phenylpropanolamine. That is 7.5% of all reports for this medicine, compared with 5.2% across reports for all dog medicines.

311Reports

89%Marked serious

0.0%Recovered

99%Died or euthanised

4 daysTypical onset

How soon it started

Same day

49 26%

1–2 days

42 22%

3–7 days

18 9.5%

1–4 weeks

23 12%

Over a month

58 31%

How the animals did

Still unwell when reported

1 0.3%

Died

125 40%

Euthanised

184 59%

Not known

1 0.3%

Problems reported at the same time

109 35%

96 31%

79 25%

69 22%

55 18%

47 15%

47 15%

41 13%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

116

12+ years

124

About this medicine

Phenylpropanolamine treats urinary incontinence.

Products with this ingredient include Proin. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Phenylpropanolamine cause death in dogs?: 311 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 4 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Death with similar medicines

Death after Trilostane (Vetoryl) 1,318 reports · 11% of its reports
Death after Insulin 624 reports · 8.5% of its reports
Death after Levothyroxine 249 reports · 8.3% of its reports

All reported side effects of Phenylpropanolamine in dogs · Medicines most reported with death