Breathing problems after Phenylpropanolamine (Proin) in dogs

The FDA has received 500 reports of breathing problems in dogs after Phenylpropanolamine. That is 12% of all reports for this medicine, compared with 2.7% across reports for all dog medicines, so it is reported unusually often with this medicine.

500Reports
46%Marked serious
52%Recovered
11%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
232 65%
1–2 days
44 12%
3–7 days
19 5.4%
1–4 weeks
10 2.8%
Over a month
50 14%

How the animals did

Recovered
258 52%
Recovered with lasting effects
4 0.8%
Still unwell when reported
40 8.0%
Died
32 6.4%
Euthanised
25 5.0%
Not known
141 28%

Problems reported at the same time

Age of the animals

Under 1 year
6
1–3 years
83
4–7 years
127
8–11 years
135
12+ years
145

About this medicine

Phenylpropanolamine treats urinary incontinence.

Products with this ingredient include Proin. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Phenylpropanolamine cause breathing problems in dogs?
500 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Breathing problems with similar medicines

All reported side effects of Phenylpropanolamine in dogs · Medicines most reported with breathing problems