Accidental exposure after Phenylpropanolamine (Proin) in dogs

The FDA has received 372 reports of accidental exposure in dogs after Phenylpropanolamine. That is 9.0% of all reports for this medicine, compared with 1.5% across reports for all dog medicines, so it is reported unusually often with this medicine.

372Reports
51%Marked serious
67%Recovered
1.3%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
225 89%
1–2 days
15 5.9%
3–7 days
0 0.0%
1–4 weeks
1 0.4%
Over a month
12 4.7%

How the animals did

Recovered
248 67%
Recovered with lasting effects
1 0.3%
Still unwell when reported
14 3.8%
Died
2 0.5%
Euthanised
3 0.8%
Not known
104 28%

Problems reported at the same time

Age of the animals

Under 1 year
51
1–3 years
123
4–7 years
98
8–11 years
72
12+ years
22

About this medicine

Phenylpropanolamine treats urinary incontinence.

Products with this ingredient include Proin. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Phenylpropanolamine cause accidental exposure in dogs?
372 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Accidental exposure with similar medicines

All reported side effects of Phenylpropanolamine in dogs · Medicines most reported with accidental exposure