Vomiting after Phenylpropanolamine (Proin) in dogs

The FDA has received 1,365 reports of vomiting in dogs after Phenylpropanolamine. That is 33% of all reports for this medicine, compared with 28% across reports for all dog medicines.

1,365Reports
34%Marked serious
63%Recovered
8.1%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
537 56%
1–2 days
104 11%
3–7 days
34 3.5%
1–4 weeks
57 5.9%
Over a month
233 24%

How the animals did

Recovered
855 63%
Recovered with lasting effects
8 0.6%
Still unwell when reported
105 7.7%
Died
45 3.3%
Euthanised
66 4.8%
Not known
286 21%

Problems reported at the same time

Age of the animals

Under 1 year
21
1–3 years
281
4–7 years
370
8–11 years
355
12+ years
320

About this medicine

Phenylpropanolamine treats urinary incontinence.

Products with this ingredient include Proin. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Phenylpropanolamine cause vomiting in dogs?
1,365 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Vomiting with similar medicines

All reported side effects of Phenylpropanolamine in dogs · Medicines most reported with vomiting