Lethargy after Phenylpropanolamine (Proin) in dogs

668 reports to the FDA describe lethargy in dogs given Phenylpropanolamine. That is 16% of all reports for this medicine, compared with 11% across reports for all dog medicines.

668Reports

42%Marked serious

51%Recovered

12%Died or euthanised

Same dayTypical onset

How soon it started

Same day

236 50%

1–2 days

91 19%

3–7 days

22 4.7%

1–4 weeks

29 6.2%

Over a month

90 19%

How the animals did

Recovered

331 50%

Recovered with lasting effects

9 1.3%

Still unwell when reported

70 10%

Died

30 4.5%

Euthanised

50 7.5%

Not known

178 27%

Problems reported at the same time

293 44%

210 31%

97 15%

87 13%

83 12%

79 12%

79 12%

71 11%

Age of the animals

Under 1 year

1–3 years

143

4–7 years

156

8–11 years

166

12+ years

169

About this medicine

Phenylpropanolamine treats urinary incontinence.

Products with this ingredient include Proin. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Phenylpropanolamine cause lethargy in dogs?: 668 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Lethargy with similar medicines

Lethargy after Trilostane (Vetoryl) 2,568 reports · 22% of its reports
Lethargy after Insulin 895 reports · 12% of its reports
Lethargy after Levothyroxine 470 reports · 16% of its reports

All reported side effects of Phenylpropanolamine in dogs · Medicines most reported with lethargy