Diarrhea after Phenylpropanolamine (Proin) in dogs

The FDA has received 383 reports of diarrhea in dogs after Phenylpropanolamine. That is 9.3% of all reports for this medicine, compared with 8.4% across reports for all dog medicines.

383Reports
46%Marked serious
50%Recovered
11%Died or euthanised
2 daysTypical onset
SponsoredWorried about your pet? Ask a veterinarian online, 24/7

How soon it started

Same day
82 31%
1–2 days
59 22%
3–7 days
27 10%
1–4 weeks
31 12%
Over a month
68 25%

How the animals did

Recovered
183 48%
Recovered with lasting effects
7 1.8%
Still unwell when reported
55 14%
Died
12 3.1%
Euthanised
30 7.8%
Not known
96 25%

Problems reported at the same time

Age of the animals

Under 1 year
3
1–3 years
40
4–7 years
78
8–11 years
123
12+ years
133

About this medicine

Phenylpropanolamine treats urinary incontinence.

Products with this ingredient include Proin. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Phenylpropanolamine cause diarrhea in dogs?
383 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 2 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Diarrhea with similar medicines

All reported side effects of Phenylpropanolamine in dogs · Medicines most reported with diarrhea