Restlessness or agitation after Phenylpropanolamine (Proin) in dogs

454 reports to the FDA describe restlessness or agitation in dogs given Phenylpropanolamine. That is 11% of all reports for this medicine, compared with 1.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

454Reports
45%Marked serious
61%Recovered
5.9%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
231 70%
1–2 days
34 10%
3–7 days
17 5.1%
1–4 weeks
16 4.8%
Over a month
33 10.0%

How the animals did

Recovered
278 61%
Recovered with lasting effects
1 0.2%
Still unwell when reported
26 5.7%
Died
10 2.2%
Euthanised
17 3.7%
Not known
122 27%

Problems reported at the same time

Age of the animals

Under 1 year
19
1–3 years
94
4–7 years
121
8–11 years
107
12+ years
110

About this medicine

Phenylpropanolamine treats urinary incontinence.

Products with this ingredient include Proin. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Phenylpropanolamine cause restlessness or agitation in dogs?
454 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Restlessness or agitation with similar medicines

All reported side effects of Phenylpropanolamine in dogs · Medicines most reported with restlessness or agitation