Restlessness or agitation after Trilostane (Vetoryl) in dogs

247 reports to the FDA describe restlessness or agitation in dogs given Trilostane. That is 2.1% of all reports for this medicine, compared with 1.6% across reports for all dog medicines.

247Reports
50%Marked serious
16%Recovered
13%Died or euthanised
28 daysTypical onset
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How soon it started

Same day
25 14%
1–2 days
15 8.5%
3–7 days
14 7.9%
1–4 weeks
39 22%
Over a month
84 47%

How the animals did

Recovered
38 15%
Recovered with lasting effects
2 0.8%
Still unwell when reported
26 11%
Died
10 4.0%
Euthanised
21 8.5%
Not known
150 61%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
0
4–7 years
15
8–11 years
104
12+ years
122

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause restlessness or agitation in dogs?
247 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 28 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Restlessness or agitation with similar medicines

All reported side effects of Trilostane in dogs · Medicines most reported with restlessness or agitation