Breathing problems after Trilostane (Vetoryl) in dogs

The FDA has received 771 reports of breathing problems in dogs after Trilostane. That is 6.5% of all reports for this medicine, compared with 2.7% across reports for all dog medicines, so it is reported unusually often with this medicine.

771Reports
60%Marked serious
13%Recovered
19%Died or euthanised
51 daysTypical onset
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How soon it started

Same day
44 8.0%
1–2 days
38 6.9%
3–7 days
49 9.0%
1–4 weeks
82 15%
Over a month
334 61%

How the animals did

Recovered
97 13%
Recovered with lasting effects
6 0.8%
Still unwell when reported
118 15%
Died
47 6.1%
Euthanised
100 13%
Not known
403 52%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
0
4–7 years
75
8–11 years
362
12+ years
312

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause breathing problems in dogs?
771 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 51 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Breathing problems with similar medicines

All reported side effects of Trilostane in dogs · Medicines most reported with breathing problems