Kidney problems after Trilostane (Vetoryl) in dogs

The FDA has received 1,689 reports of kidney problems in dogs after Trilostane. That is 14% of all reports for this medicine, compared with 2.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

1,689Reports
64%Marked serious
3.1%Recovered
23%Died or euthanised
48 daysTypical onset
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How soon it started

Same day
39 3.2%
1–2 days
50 4.1%
3–7 days
103 8.5%
1–4 weeks
302 25%
Over a month
715 59%

How the animals did

Recovered
47 2.8%
Recovered with lasting effects
6 0.4%
Still unwell when reported
281 17%
Died
118 7.0%
Euthanised
273 16%
Not known
964 57%

Problems reported at the same time

474 28%
460 27%
385 23%
315 19%

Age of the animals

Under 1 year
1
1–3 years
0
4–7 years
89
8–11 years
641
12+ years
924

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause kidney problems in dogs?
1,689 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 48 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Kidney problems with similar medicines

All reported side effects of Trilostane in dogs · Medicines most reported with kidney problems