Liver problems after Trilostane (Vetoryl) in dogs

The FDA has received 2,663 reports of liver problems in dogs after Trilostane. That is 22% of all reports for this medicine, compared with 4.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

2,663Reports

52%Marked serious

3.0%Recovered

14%Died or euthanised

53 daysTypical onset

How soon it started

Same day

67 3.5%

1–2 days

48 2.5%

3–7 days

128 6.8%

1–4 weeks

483 26%

Over a month

1,162 62%

How the animals did

Recovered

62 2.3%

Recovered with lasting effects

19 0.7%

Still unwell when reported

385 14%

Died

95 3.6%

Euthanised

267 10%

Not known

1,835 69%

Problems reported at the same time

725 27%

724 27%

616 23%

565 21%

Elevated gamma-glutamyl transferase (ggt)

505 19%

Vomiting

485 18%

Weight loss

435 16%

Didn't work as expected

423 16%

Age of the animals

Under 1 year

1–3 years

4–7 years

234

8–11 years

1,269

12+ years

1,109

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause liver problems in dogs?: 2,663 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 53 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

Liver problems after Insulin 417 reports · 5.7% of its reports
Liver problems after Phenylpropanolamine (Proin) 289 reports · 7.0% of its reports
Liver problems after Levothyroxine 319 reports · 11% of its reports

All reported side effects of Trilostane in dogs · Medicines most reported with liver problems