Elevated gamma-glutamyl transferase (ggt) after Trilostane (Vetoryl) in dogs

551 reports to the FDA describe elevated gamma-glutamyl transferase (ggt) in dogs given Trilostane. That is 4.6% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

551Reports
57%Marked serious
1.8%Recovered
16%Died or euthanised
47 daysTypical onset
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How soon it started

Same day
10 2.5%
1–2 days
12 2.9%
3–7 days
27 6.6%
1–4 weeks
118 29%
Over a month
241 59%

How the animals did

Recovered
5 0.9%
Recovered with lasting effects
5 0.9%
Still unwell when reported
89 16%
Died
25 4.5%
Euthanised
64 12%
Not known
363 66%

Problems reported at the same time

Age of the animals

Under 1 year
1
1–3 years
0
4–7 years
53
8–11 years
279
12+ years
209

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause elevated gamma-glutamyl transferase (ggt) in dogs?
551 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 47 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Elevated gamma-glutamyl transferase (ggt) with similar medicines

All reported side effects of Trilostane in dogs · Medicines most reported with elevated gamma-glutamyl transferase (ggt)