Death after Trilostane (Vetoryl) in dogs

The FDA has received 1,318 reports of death in dogs after Trilostane. That is 11% of all reports for this medicine, compared with 5.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

1,318Reports

97%Marked serious

0.0%Recovered

99%Died or euthanised

28 daysTypical onset

How soon it started

Same day

75 7.5%

1–2 days

81 8.1%

3–7 days

124 12%

1–4 weeks

244 24%

Over a month

478 48%

How the animals did

Still unwell when reported

5 0.4%

Died

418 32%

Euthanised

893 68%

Not known

2 0.2%

Problems reported at the same time

583 44%

422 32%

385 29%

372 28%

356 27%

272 21%

223 17%

191 14%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

545

12+ years

618

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause death in dogs?: 1,318 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 28 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Death with similar medicines

Death after Insulin 624 reports · 8.5% of its reports
Death after Phenylpropanolamine (Proin) 311 reports · 7.5% of its reports
Death after Levothyroxine 249 reports · 8.3% of its reports

All reported side effects of Trilostane in dogs · Medicines most reported with death