Excessive thirst after Trilostane (Vetoryl) in dogs

The FDA has received 873 reports of excessive thirst in dogs after Trilostane. That is 7.3% of all reports for this medicine, compared with 1.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

873Reports
60%Marked serious
9.7%Recovered
11%Died or euthanised
66 daysTypical onset
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How soon it started

Same day
40 6.6%
1–2 days
10 1.6%
3–7 days
34 5.6%
1–4 weeks
131 22%
Over a month
394 65%

How the animals did

Recovered
81 9.3%
Recovered with lasting effects
4 0.5%
Still unwell when reported
178 20%
Died
19 2.2%
Euthanised
78 8.9%
Not known
513 59%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
1
4–7 years
79
8–11 years
421
12+ years
355

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause excessive thirst in dogs?
873 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 66 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Excessive thirst with similar medicines

All reported side effects of Trilostane in dogs · Medicines most reported with excessive thirst