Eye or vision problems after Phenylpropanolamine (Proin) in dogs

The FDA has received 178 reports of eye or vision problems in dogs after Phenylpropanolamine. That is 4.3% of all reports for this medicine, compared with 0.7% across reports for all dog medicines, so it is reported unusually often with this medicine.

178Reports
71%Marked serious
58%Recovered
9.6%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
93 71%
1–2 days
13 9.9%
3–7 days
6 4.6%
1–4 weeks
7 5.3%
Over a month
12 9.2%

How the animals did

Recovered
101 57%
Recovered with lasting effects
3 1.7%
Still unwell when reported
14 7.9%
Died
3 1.7%
Euthanised
14 7.9%
Not known
43 24%

Problems reported at the same time

Age of the animals

Under 1 year
9
1–3 years
68
4–7 years
47
8–11 years
36
12+ years
17

About this medicine

Phenylpropanolamine treats urinary incontinence.

Products with this ingredient include Proin. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Phenylpropanolamine cause eye or vision problems in dogs?
178 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Eye or vision problems with similar medicines

All reported side effects of Phenylpropanolamine in dogs · Medicines most reported with eye or vision problems