Drooling after Phenylpropanolamine (Proin) in dogs

The FDA has received 130 reports of drooling in dogs after Phenylpropanolamine. That is 3.1% of all reports for this medicine, compared with 1.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

130Reports
49%Marked serious
61%Recovered
11%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
65 68%
1–2 days
12 13%
3–7 days
7 7.3%
1–4 weeks
2 2.1%
Over a month
10 10%

How the animals did

Recovered
79 61%
Still unwell when reported
7 5.4%
Died
8 6.2%
Euthanised
6 4.6%
Not known
30 23%

Problems reported at the same time

Age of the animals

Under 1 year
6
1–3 years
28
4–7 years
36
8–11 years
30
12+ years
27

About this medicine

Phenylpropanolamine treats urinary incontinence.

Products with this ingredient include Proin. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Phenylpropanolamine cause drooling in dogs?
130 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Drooling with similar medicines

All reported side effects of Phenylpropanolamine in dogs · Medicines most reported with drooling