Seizures after Phenylpropanolamine (Proin) in dogs

195 reports to the FDA describe seizures in dogs given Phenylpropanolamine. That is 4.7% of all reports for this medicine, compared with 4.4% across reports for all dog medicines.

195Reports

73%Marked serious

40%Recovered

24%Died or euthanised

5 daysTypical onset

How soon it started

Same day

34 27%

1–2 days

23 18%

3–7 days

14 11%

1–4 weeks

9 7.1%

Over a month

46 37%

How the animals did

Recovered

76 39%

Recovered with lasting effects

2 1.0%

Still unwell when reported

21 11%

Died

12 6.2%

Euthanised

35 18%

Not known

49 25%

Problems reported at the same time

47 24%

38 19%

36 18%

25 13%

21 11%

20 10%

18 9.2%

16 8.2%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Phenylpropanolamine treats urinary incontinence.

Products with this ingredient include Proin. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Phenylpropanolamine cause seizures in dogs?: 195 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 5 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Seizures with similar medicines

Seizures after Trilostane (Vetoryl) 367 reports · 3.1% of its reports
Seizures after Insulin 396 reports · 5.4% of its reports
Seizures after Levothyroxine 206 reports · 6.8% of its reports

All reported side effects of Phenylpropanolamine in dogs · Medicines most reported with seizures