Behaviour change after Phenylpropanolamine (Proin) in dogs

The FDA has received 210 reports of behaviour change in dogs after Phenylpropanolamine. That is 5.1% of all reports for this medicine, compared with 2.5% across reports for all dog medicines, so it is reported unusually often with this medicine.

210Reports
39%Marked serious
50%Recovered
6.7%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
64 46%
1–2 days
16 12%
3–7 days
8 5.8%
1–4 weeks
10 7.2%
Over a month
40 29%

How the animals did

Recovered
98 47%
Recovered with lasting effects
6 2.9%
Still unwell when reported
30 14%
Died
4 1.9%
Euthanised
10 4.8%
Not known
62 30%

Problems reported at the same time

Age of the animals

Under 1 year
6
1–3 years
35
4–7 years
54
8–11 years
53
12+ years
58

About this medicine

Phenylpropanolamine treats urinary incontinence.

Products with this ingredient include Proin. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Phenylpropanolamine cause behaviour change in dogs?
210 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Behaviour change with similar medicines

All reported side effects of Phenylpropanolamine in dogs · Medicines most reported with behaviour change