Behaviour change after Trilostane (Vetoryl) in dogs

445 reports to the FDA describe behaviour change in dogs given Trilostane. That is 3.7% of all reports for this medicine, compared with 2.5% across reports for all dog medicines.

445Reports
51%Marked serious
17%Recovered
14%Died or euthanised
35 daysTypical onset
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How soon it started

Same day
28 8.5%
1–2 days
18 5.4%
3–7 days
20 6.0%
1–4 weeks
85 26%
Over a month
180 54%

How the animals did

Recovered
70 16%
Recovered with lasting effects
6 1.3%
Still unwell when reported
62 14%
Died
13 2.9%
Euthanised
49 11%
Not known
245 55%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
0
4–7 years
42
8–11 years
226
12+ years
170

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause behaviour change in dogs?
445 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 35 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Behaviour change with similar medicines

All reported side effects of Trilostane in dogs · Medicines most reported with behaviour change