Didn't work as expected after Phenylpropanolamine (Proin) in dogs

The FDA has received 702 reports of didn't work as expected in dogs after Phenylpropanolamine. That is 17% of all reports for this medicine, compared with 13% across reports for all dog medicines.

702Reports
27%Marked serious
22%Recovered
3.8%Died or euthanised
7 daysTypical onset
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How soon it started

Same day
57 15%
1–2 days
86 23%
3–7 days
61 16%
1–4 weeks
57 15%
Over a month
121 32%

How the animals did

Recovered
150 21%
Recovered with lasting effects
5 0.7%
Still unwell when reported
78 11%
Died
13 1.9%
Euthanised
14 2.0%
Not known
442 63%

Problems reported at the same time

Underdose
108 15%
Overdose
71 10%
Vomiting
41 5.8%
Loss of appetite
40 5.7%
Urinary incontinence
37 5.3%
Lethargy
33 4.7%
Excessive thirst
29 4.1%
Urinary tract infection
29 4.1%

Age of the animals

Under 1 year
6
1–3 years
65
4–7 years
155
8–11 years
226
12+ years
208

About this medicine

Phenylpropanolamine treats urinary incontinence.

Products with this ingredient include Proin. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Phenylpropanolamine cause didn't work as expected in dogs?
702 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 7 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Didn't work as expected with similar medicines

All reported side effects of Phenylpropanolamine in dogs · Medicines most reported with didn't work as expected