Urinary incontinence after Phenylpropanolamine (Proin) in dogs

123 reports to the FDA describe urinary incontinence in dogs given Phenylpropanolamine. That is 3.0% of all reports for this medicine, compared with 0.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

123Reports
48%Marked serious
15%Recovered
7.3%Died or euthanised
20 daysTypical onset
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How soon it started

Same day
8 11%
1–2 days
9 12%
3–7 days
11 15%
1–4 weeks
15 20%
Over a month
32 43%

How the animals did

Recovered
13 11%
Recovered with lasting effects
6 4.9%
Still unwell when reported
51 41%
Died
2 1.6%
Euthanised
7 5.7%
Not known
44 36%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
8
4–7 years
36
8–11 years
35
12+ years
41

About this medicine

Phenylpropanolamine treats urinary incontinence.

Products with this ingredient include Proin. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Phenylpropanolamine cause urinary incontinence in dogs?
123 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 20 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Urinary incontinence with similar medicines

All reported side effects of Phenylpropanolamine in dogs · Medicines most reported with urinary incontinence