Urinary incontinence after Trilostane (Vetoryl) in dogs

The FDA has received 123 reports of urinary incontinence in dogs after Trilostane. That is 1.0% of all reports for this medicine, compared with 0.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

123Reports
60%Marked serious
11%Recovered
18%Died or euthanised
59 daysTypical onset
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How soon it started

Same day
5 5.5%
1–2 days
4 4.4%
3–7 days
4 4.4%
1–4 weeks
17 19%
Over a month
61 67%

How the animals did

Recovered
12 9.8%
Recovered with lasting effects
1 0.8%
Still unwell when reported
31 25%
Died
3 2.4%
Euthanised
19 15%
Not known
57 46%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
0
4–7 years
7
8–11 years
44
12+ years
69

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause urinary incontinence in dogs?
123 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 59 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Urinary incontinence with similar medicines

All reported side effects of Trilostane in dogs · Medicines most reported with urinary incontinence