Underdose after Phenylpropanolamine (Proin) in dogs

The FDA has received 316 reports of underdose in dogs after Phenylpropanolamine. That is 7.6% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

316Reports
37%Marked serious
50%Recovered
4.4%Died or euthanised
2 daysTypical onset
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How soon it started

Same day
47 37%
1–2 days
22 17%
3–7 days
12 9.5%
1–4 weeks
12 9.5%
Over a month
33 26%

How the animals did

Recovered
155 49%
Recovered with lasting effects
2 0.6%
Still unwell when reported
24 7.6%
Died
7 2.2%
Euthanised
7 2.2%
Not known
121 38%

Problems reported at the same time

Age of the animals

Under 1 year
5
1–3 years
46
4–7 years
85
8–11 years
106
12+ years
71

About this medicine

Phenylpropanolamine treats urinary incontinence.

Products with this ingredient include Proin. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Phenylpropanolamine cause underdose in dogs?
316 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 2 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Underdose with similar medicines

All reported side effects of Phenylpropanolamine in dogs · Medicines most reported with underdose