Underdose after Trilostane (Vetoryl) in dogs

The FDA has received 1,431 reports of underdose in dogs after Trilostane. That is 12% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

1,431Reports
42%Marked serious
20%Recovered
9.4%Died or euthanised
35 daysTypical onset
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How soon it started

Same day
41 3.8%
1–2 days
61 5.6%
3–7 days
91 8.4%
1–4 weeks
302 28%
Over a month
594 55%

How the animals did

Recovered
273 19%
Recovered with lasting effects
10 0.7%
Still unwell when reported
124 8.7%
Died
39 2.7%
Euthanised
95 6.6%
Not known
890 62%

Problems reported at the same time

Age of the animals

Under 1 year
2
1–3 years
2
4–7 years
115
8–11 years
645
12+ years
640

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause underdose in dogs?
1,431 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 35 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Underdose with similar medicines

All reported side effects of Trilostane in dogs · Medicines most reported with underdose