Wobbliness (ataxia) after Phenylpropanolamine (Proin) in dogs

192 reports to the FDA describe wobbliness (ataxia) in dogs given Phenylpropanolamine. That is 4.6% of all reports for this medicine, compared with 2.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

192Reports
61%Marked serious
45%Recovered
15%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
43 34%
1–2 days
34 27%
3–7 days
6 4.8%
1–4 weeks
10 7.9%
Over a month
33 26%

How the animals did

Recovered
80 42%
Recovered with lasting effects
6 3.1%
Still unwell when reported
38 20%
Died
13 6.8%
Euthanised
15 7.8%
Not known
40 21%

Problems reported at the same time

Age of the animals

Under 1 year
1
1–3 years
18
4–7 years
27
8–11 years
48
12+ years
97

About this medicine

Phenylpropanolamine treats urinary incontinence.

Products with this ingredient include Proin. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Phenylpropanolamine cause wobbliness (ataxia) in dogs?
192 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Wobbliness (ataxia) with similar medicines

All reported side effects of Phenylpropanolamine in dogs · Medicines most reported with wobbliness (ataxia)