Wobbliness (ataxia) after Trilostane (Vetoryl) in dogs

226 reports to the FDA describe wobbliness (ataxia) in dogs given Trilostane. That is 1.9% of all reports for this medicine, compared with 2.6% across reports for all dog medicines.

226Reports
58%Marked serious
22%Recovered
20%Died or euthanised
21 daysTypical onset
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How soon it started

Same day
25 14%
1–2 days
12 6.7%
3–7 days
27 15%
1–4 weeks
40 22%
Over a month
76 42%

How the animals did

Recovered
45 20%
Recovered with lasting effects
4 1.8%
Still unwell when reported
35 15%
Died
11 4.9%
Euthanised
35 15%
Not known
96 42%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
2
4–7 years
15
8–11 years
100
12+ years
105

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause wobbliness (ataxia) in dogs?
226 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 21 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Wobbliness (ataxia) with similar medicines

All reported side effects of Trilostane in dogs · Medicines most reported with wobbliness (ataxia)