Weakness after Trilostane (Vetoryl) in dogs

The FDA has received 851 reports of weakness in dogs after Trilostane. That is 7.1% of all reports for this medicine, compared with 1.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

851Reports

61%Marked serious

19%Recovered

20%Died or euthanised

31 daysTypical onset

How soon it started

Same day

45 6.7%

1–2 days

44 6.5%

3–7 days

90 13%

1–4 weeks

156 23%

Over a month

339 50%

How the animals did

Recovered

153 18%

Recovered with lasting effects

7 0.8%

Still unwell when reported

108 13%

Died

43 5.1%

Euthanised

125 15%

Not known

415 49%

Problems reported at the same time

337 40%

308 36%

207 24%

192 23%

166 20%

166 20%

157 18%

156 18%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

366

12+ years

408

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause weakness in dogs?: 851 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 31 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Weakness with similar medicines

Weakness after Insulin 238 reports · 3.2% of its reports
Weakness after Phenylpropanolamine (Proin) 140 reports · 3.4% of its reports
Weakness after Levothyroxine 144 reports · 4.8% of its reports

All reported side effects of Trilostane in dogs · Medicines most reported with weakness