Weakness after Phenylpropanolamine (Proin) in dogs

140 reports to the FDA describe weakness in dogs given Phenylpropanolamine. That is 3.4% of all reports for this medicine, compared with 1.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

140Reports

65%Marked serious

29%Recovered

25%Died or euthanised

4 daysTypical onset

How soon it started

Same day

23 26%

1–2 days

20 22%

3–7 days

6 6.7%

1–4 weeks

10 11%

Over a month

31 34%

How the animals did

Recovered

38 27%

Recovered with lasting effects

3 2.1%

Still unwell when reported

31 22%

Died

9 6.4%

Euthanised

26 19%

Not known

33 24%

Problems reported at the same time

53 38%

42 30%

37 26%

34 24%

33 24%

33 24%

23 16%

20 14%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Phenylpropanolamine treats urinary incontinence.

Products with this ingredient include Proin. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Phenylpropanolamine cause weakness in dogs?: 140 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 4 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Weakness with similar medicines

Weakness after Trilostane (Vetoryl) 851 reports · 7.1% of its reports
Weakness after Insulin 238 reports · 3.2% of its reports
Weakness after Levothyroxine 144 reports · 4.8% of its reports

All reported side effects of Phenylpropanolamine in dogs · Medicines most reported with weakness