Blood problems after Phenylpropanolamine (Proin) in dogs

The FDA has received 87 reports of blood problems in dogs after Phenylpropanolamine. That is 2.1% of all reports for this medicine, compared with 1.8% across reports for all dog medicines.

87Reports

83%Marked serious

10%Recovered

38%Died or euthanised

17 daysTypical onset

How soon it started

Same day

7 14%

1–2 days

4 8.0%

3–7 days

8 16%

1–4 weeks

12 24%

Over a month

19 38%

How the animals did

Recovered

8 9.2%

Recovered with lasting effects

1 1.1%

Still unwell when reported

28 32%

Died

8 9.2%

Euthanised

25 29%

Not known

17 20%

Problems reported at the same time

39 45%

37 43%

35 40%

34 39%

32 37%

31 36%

18 21%

17 20%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Phenylpropanolamine treats urinary incontinence.

Products with this ingredient include Proin. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Phenylpropanolamine cause blood problems in dogs?: 87 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 17 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Blood problems with similar medicines

Blood problems after Trilostane (Vetoryl) 252 reports · 2.1% of its reports
Blood problems after Insulin 89 reports · 1.2% of its reports
Blood problems after Levothyroxine 104 reports · 3.5% of its reports

All reported side effects of Phenylpropanolamine in dogs · Medicines most reported with blood problems