Low sodium-potassium ratio (na:k ratio) after Trilostane (Vetoryl) in dogs

The FDA has received 844 reports of low sodium-potassium ratio (na:k ratio) in dogs after Trilostane. That is 7.1% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

844Reports
51%Marked serious
5.8%Recovered
12%Died or euthanised
54 daysTypical onset
SponsoredWorried about your pet? Ask a veterinarian online, 24/7

How soon it started

Same day
16 2.6%
1–2 days
14 2.3%
3–7 days
37 6.0%
1–4 weeks
157 25%
Over a month
394 64%

How the animals did

Recovered
45 5.3%
Recovered with lasting effects
4 0.5%
Still unwell when reported
139 16%
Died
25 3.0%
Euthanised
76 9.0%
Not known
555 66%

Problems reported at the same time

Age of the animals

Under 1 year
1
1–3 years
1
4–7 years
32
8–11 years
323
12+ years
475

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause low sodium-potassium ratio (na:k ratio) in dogs?
844 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 54 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Low sodium-potassium ratio (na:k ratio) with similar medicines

All reported side effects of Trilostane in dogs · Medicines most reported with low sodium-potassium ratio (na:k ratio)