Hyponatremia after Trilostane (Vetoryl) in dogs

465 reports to the FDA describe hyponatremia in dogs given Trilostane. That is 3.9% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

465Reports

70%Marked serious

6.5%Recovered

20%Died or euthanised

44 daysTypical onset

How soon it started

Same day

7 2.0%

1–2 days

9 2.5%

3–7 days

33 9.3%

1–4 weeks

92 26%

Over a month

212 60%

How the animals did

Recovered

26 5.6%

Recovered with lasting effects

4 0.9%

Still unwell when reported

98 21%

Died

31 6.7%

Euthanised

61 13%

Not known

245 53%

Problems reported at the same time

Hyperkalaemia

298 64%

Loss of appetite

220 47%

Low sodium-potassium ratio (na:k ratio)

173 37%

172 37%

165 35%

152 33%

150 32%

137 29%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

253

12+ years

178

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause hyponatremia in dogs?: 465 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 44 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hyponatremia with similar medicines

Hyponatremia after Insulin 128 reports · 1.7% of its reports

All reported side effects of Trilostane in dogs · Medicines most reported with hyponatremia