Thrombocytosis after Trilostane (Vetoryl) in dogs

453 reports to the FDA describe thrombocytosis in dogs given Trilostane. That is 3.8% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

453Reports
53%Marked serious
2.4%Recovered
11%Died or euthanised
61 daysTypical onset
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How soon it started

Same day
6 1.8%
1–2 days
3 0.9%
3–7 days
12 3.6%
1–4 weeks
80 24%
Over a month
232 70%

How the animals did

Recovered
5 1.1%
Recovered with lasting effects
6 1.3%
Still unwell when reported
75 17%
Died
8 1.8%
Euthanised
41 9.1%
Not known
318 70%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
0
4–7 years
22
8–11 years
170
12+ years
255

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause thrombocytosis in dogs?
453 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 61 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Thrombocytosis with similar medicines

All reported side effects of Trilostane in dogs · Medicines most reported with thrombocytosis