Amitraz + Fipronil + S-methoprene side effects in dogs
460 reports sent to the FDA between 2011 and 2018 involve Amitraz + Fipronil + S-methoprene in dogs. The most reported problems were lethargy, vomiting, application site reaction. 73% were marked serious.
460Reports
73%Marked serious
0.0%Only medicine involved
51%Recovered
0.9%Died or euthanised
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About this medicine
Fipronil kills fleas and ticks (spot-on).
Most reported side effects
Share = percentage of this medicine's reports that mention the problem. One report can list several problems.
Reports that it didn't work
Some reports are about the medicine not working (for example a dog still getting fleas or heartworm), not about a side effect.
How soon problems started
Time from the first dose to the first sign, where both dates were reported (336 reports).
How the animals did
Breeds named most often
Popular breeds appear more often because there are more of them.
- Labrador Retriever 66 reports
- Dog (other) 43 reports
- Golden Retriever 22 reports
- German Shepherd Dog 20 reports
- Siberian Husky 17 reports
- Australian Shepherd Dog 12 reports
- Shetland Sheepdog 12 reports
- Border Collie 10 reports
- German Pomeranian Spitz 7 reports
- Maltese 7 reports
Other flea and tick treatments for dogs
Spinosad (Comfortis)57,095 reports · 7.7% seriousLufenuron + Milbemycin Oxime (Sentinel)26,051 reports · 24% seriousImidacloprid + Moxidectin (Advantage Multi)13,117 reports · 57% seriousNitenpyram (Capstar)10,782 reports · 10.0% seriousLufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum)9,966 reports · 40% seriousFipronil + S-methoprene (Frontline Plus)2,954 reports · 49% seriousFlumethrin + Imidacloprid (Seresto)2,273 reports · 25% seriousImidacloprid1,908 reports · 11% serious