Elevated gamma-glutamyl transferase (ggt) after Polysulfated Glycosaminoglycan in dogs

The FDA has received 52 reports of elevated gamma-glutamyl transferase (ggt) in dogs after Polysulfated Glycosaminoglycan. That is 1.0% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

52Reports
73%Marked serious
5.8%Recovered
27%Died or euthanised
35 daysTypical onset
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How soon it started

Same day
4 12%
1–2 days
3 9.1%
3–7 days
4 12%
1–4 weeks
4 12%
Over a month
18 55%

How the animals did

Recovered
2 3.8%
Recovered with lasting effects
1 1.9%
Still unwell when reported
17 33%
Died
6 12%
Euthanised
8 15%
Not known
18 35%

Problems reported at the same time

Liver problems
42 81%
Loss of appetite
29 56%
Vomiting
22 42%
Lethargy
21 40%
Kidney problems
18 35%
Death
15 29%
Elevated cholesterol (total)
15 29%
Weight loss
12 23%

Age of the animals

Under 1 year
0
1–3 years
3
4–7 years
5
8–11 years
24
12+ years
19

About this medicine

Type: medicine.

Questions owners ask

Can Polysulfated Glycosaminoglycan cause elevated gamma-glutamyl transferase (ggt) in dogs?
52 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 35 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Elevated gamma-glutamyl transferase (ggt) with similar medicines

All reported side effects of Polysulfated Glycosaminoglycan in dogs · Medicines most reported with elevated gamma-glutamyl transferase (ggt)