Elevated gamma-glutamyl transferase (ggt) after Dirlotapide in dogs

The FDA has received 22 reports of elevated gamma-glutamyl transferase (ggt) in dogs after Dirlotapide. That is 0.8% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

22Reports
0.0%Marked serious
0.0%Recovered
18%Died or euthanised
–Typical onset
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How the animals did

Still unwell when reported
2 9.1%
Died
4 18%
Not known
16 73%

Problems reported at the same time

Liver problems
20 91%
Vomiting
8 36%
Kidney problems
8 36%
Loss of appetite
7 32%
Lethargy
5 23%
Death
4 18%
Excessive thirst
4 18%
Excessive urination
4 18%

Age of the animals

Under 1 year
1
1–3 years
4
4–7 years
8
8–11 years
6
12+ years
3

About this medicine

Type: medicine.

Questions owners ask

Can Dirlotapide cause elevated gamma-glutamyl transferase (ggt) in dogs?
22 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Elevated gamma-glutamyl transferase (ggt) with similar medicines

All reported side effects of Dirlotapide in dogs · Medicines most reported with elevated gamma-glutamyl transferase (ggt)